|
KMID : 1151820200140040439
|
|
Journal of the Korean Society of Radiology
2020 Volume.14 No. 4 p.439 ~ p.445
|
|
|
A Mouse Colon Model to Investigate Stent-Induced Tissue Hyperplasia
|
|
Kim Min-Tae
|
|
|
Abstract
|
|
|
|
The purpose of this study was to investigate the feasibility of stent placement and the evaluation of tissue hyperplasia caused by bare metallic stent placement in a mouse colon model. In a pilot study, C57BL/6 mouse were used to verify diameter of colon. Mean diameter size was 4.05 mm. Twenty C57BL/6 mice were divided into two groups to assess differing stent diameters (Group A, 5 mm diameter; Group B. Group B, 4 mm diameter). Follow-up, 1-week fluoroscopic imaging, 4-week endoscopic imaging were obtained. Mice were sacrificed 4-week after stent placement. Microscopic findings were evaluated. Stent placement was technically successful except one mouse in Group A. Data from the mouse was omitted. During follow-up, five mice in Group A died within 7 days after stent placement, and one stent in Group B was migrated into the rectum. The incidence of stent-related complication was 60% and 10% between group A and Group B, respectively. Gross and Endoscopic findings showed tissue hyperplasia through the mesh, and all the stents had become incorporated into the wall of the colon. Microscopic findings were no statistically significant difference. colonic stent placement was technically feasible, and stent-induced tissue hyperplasia was evident in a mouse model. With stent large size, there was the highest incidence of colon perforation.
|
|
|
KEYWORD
|
|
|
Tissue hyperplasia , colonic stricture , colon obstruction , stent induced stricture model
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|